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Acknowledgments We thank the UK Biobank study, and the summary statistics data of UKB can be download from Neale lab ( and other GWAS summary-level data, which have been downloaded from We also thank all the reviewers and editors for their useful suggestions for improving this study

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NAD+ supports metabolic function and energy production, which can complement a weight loss program

All AEs, whether reported by the participant or observed by the study staff, will be documented

And anyone managing complex medical conditions or taking multiple medications should discuss new supplements with their healthcare provider to rule out interactions